Hodgkin's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Hodgkin's Disease, including details on causes, cancer, lymphoma, stages, symptoms.

Usefulness of multiparametric flow cytometry in detecting composite lymphoma: study of 17 cases in a 12-year period.

Demurtas A, Aliberti S, Bonello L, Di Celle PF, Cavaliere C, Barreca A, Novero D, Stacchini A

Flow Cytometry Unit, Pathology Department, Centre for Experimental Research and Medical Studies, Molinette Hospital, University of Turin, Italy.

Composite lymphoma (CL) is a rare occurrence of 2 or more morphologically and immunophenotypically distinct lymphoma clones in a single anatomic site. A retrospective analysis of 1,722 solid tissue samples clinically suggestive of lymphoma was carried out in our institute during a 12-year period to evaluate the efficacy of flow cytometry (FC) in identifying CL. We report 17 CL cases. A strong correlation between morphologic findings and FC was observed in 13 cases (76%). In the 4 cases diagnosed as non-Hodgkin lymphoma plus Hodgkin lymphoma, although FC did not detect Reed-Sternberg cells, it accurately identified the neoplastic B- or T-cell component. In 3 cases, FC indicated the need to evaluate an additional neoplastic component that was not morphologically evident. Our data demonstrate that FC immunophenotyping of tissues may enhance the performance of the diagnostic morphologic evaluation of CL. To the best of our knowledge, this is the first report in the literature of a wide series of CL studied also by FC.

Published 17 March 2011 in Am J Clin Pathol, 135(4): 541-55.
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Articles on Hodgkin's Disease published 28 February 2011:

Cardiac magnetic resonance imaging findings in 20-year survivors of mediastinal radiotherapy for Hodgkin's disease.   Int J Radiat Oncol Biol Phys, 79(4): 1117-23.

[Abstract] [Full-text]

Articles on Hodgkin's Disease published 23 February 2011:

Adolescent hodgkin lymphoma: are treatment results more favorable with pediatric than with adult regimens?   J Pediatr Hematol Oncol, 33(2): e60-3.

[Abstract] [Full-text]

Articles on Hodgkin's Disease published 17 February 2011:

Chemotherapy alone versus chemotherapy plus radiotherapy for early stage Hodgkin lymphoma.   Cochrane Database Syst Rev, 2: CD007110.

[Abstract] [Full-text]

Articles on Hodgkin's Disease published 1 February 2011:

Impact of 18F-fluoro-2-deoxyglucose positron emission tomography on treatment strategy and radiotherapy planning for stage I-II Hodgkin disease: a prospective multicenter study.   Int J Radiat Oncol Biol Phys, 79(3): 823-8.

[Abstract] [Full-text]

Impact of 18F-fluoro-2-deoxyglucose positron emission tomography on treatment strategy and radiotherapy planning for stage I-II Hodgkin disease: a prospective multicenter study.   Int J Radiat Oncol Biol Phys, 79(3): 823-8.

[Abstract] [Full-text]

Impact of 18F-fluoro-2-deoxyglucose positron emission tomography on treatment strategy and radiotherapy planning for stage I-II Hodgkin disease: a prospective multicenter study.   Int J Radiat Oncol Biol Phys, 79(3): 823-8.

[Abstract] [Full-text]

Articles on Hodgkin's Disease published 31 January 2011:

A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis.   Int J Cancer, 128(6): 1481-5.

Interaction between CD40 and its ligand, CD154, has a key function in immune regulation. Recent experimental data support a role of deregulated CD40 signalling in lymphomagenesis. Data from earlier studies that are part of this pooling study implicate a functional polymorphism (-1C>T, rs1883832) in the TNFRSF5 gene encoding CD40 in the etiology of follicular lymphoma. Here, the association of this variant with non-Hodgkin lymphoma (NHL) risk was replicated in a European multicenter study of ... [Abstract] [Full-text]

A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis.   Int J Cancer, 128(6): 1481-5.

Interaction between CD40 and its ligand, CD154, has a key function in immune regulation. Recent experimental data support a role of deregulated CD40 signalling in lymphomagenesis. Data from earlier studies that are part of this pooling study implicate a functional polymorphism (-1C>T, rs1883832) in the TNFRSF5 gene encoding CD40 in the etiology of follicular lymphoma. Here, the association of this variant with non-Hodgkin lymphoma (NHL) risk was replicated in a European multicenter study of ... [Abstract] [Full-text]

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