Hodgkin's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Hodgkin's Disease, including details on causes, cancer, lymphoma, stages, symptoms.

Expression of the translation initiation factors eIF-4E and eIF-2* is frequently increased in neoplastic cells of Hodgkin lymphoma.

Rosenwald IB, Koifman L, Savas L, Chen JJ, Woda BA, Kadin ME

Department of Pathology, New England Medical Center, Boston, MA 02111, USA. irozenvald@tufts-nemc.org

The rate of protein synthesis is regulated in part by 2 key translation initiation factors, eIF-4E and eIF-2*. The expression and activity of both factors are increased transiently when normal resting cells are stimulated to proliferate, but they are constitutively elevated in oncogene-transformed cultured cells. Overexpression of either initiation factor induces a tumorigenic phenotype in rodent cells. We have shown earlier that expression of both eIF-4E and eIF-2* is increased in non-Hodgkin lymphomas (non-HLs). In this study, we performed an immunohistochemical survey of these translation initiation factors in neoplastic cells of HL. We also used Western blot to addressed the possibility that eIF-4E increases expression of NFkappaB. Our results indicate that both eIF-4E and eIF-2* are strongly expressed in neoplastic cells of HL in most cases examined as compared with weak or undetectable expression in most surrounding lymphocytes. An increase in eIF-4E expression may lead to constitutively high expression of NFkappaB, a transcription factor implicated in resistance to apoptosis and induction of cytokine gene expression in various cells, including neoplastic cells of HL.

Published 9 June 2008 in Hum Pathol, 39(6): 910-6.
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Articles on Hodgkin's Disease published 19 May 2008:

Classical Hodgkin lymphoma concurrently evolving in a patient with marginal zone B-cell lymphoma of the spleen.   Ann Diagn Pathol, 12(3): 212-6.

Combination of the splenic marginal zone B-cell lymphoma (SMZL) and classical Hodgkin lymphoma (cHL) is extremely rare. We report a unique case with concurrent SMZL and cHL. The patient was a 63-year-old man who presented with fatigue and anemia, showing a splenomegaly and retroperitoneal lymphadenopathy. A splenectomy revealed monotonous marginal zone lymphocytic infiltrates and numerous large Reed-Sternberg-like cells. Flow cytometry revealed a kappa light-chain-restricted CD5 (-), CD23 (-) ... [Abstract] [Full-text]

Articles on Hodgkin's Disease published 16 May 2008:

Age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorders: special references to lymphomas surrounding this newly recognized clinicopathologic disease.   Cancer Sci, 99(6): 1085-91.

Epstein-Barr virus (EBV) is associated with some disease entities of malignant lymphomas, including Burkitt lymphoma, Hodgkin lymphoma, immunodeficiency-associated lymphoproliferative disorders (LPD), and a part of diffuse large B-cell lymphoma. We have recently identified a series of elderly patients with EBV-associated (or EBV(+)) B-cell LPD (B-LPD) showing similarities in many respects to immunodeficiency-associated LPD, although no evidence of underlying immunodeficiency was found. ... [Abstract] [Full-text]

Articles on Hodgkin's Disease published 13 May 2008:

Health practice in long-term survivors of Hodgkin's lymphoma.   Int J Radiat Oncol Biol Phys, 71(2): 468-76.

PURPOSE: To compare the health practice of Hodgkin's lymphoma (HL) survivors and their siblings, and to assess the impact of socioeconomic status and disease history on health practice of HL survivors. METHODS AND MATERIALS: We conducted a questionnaire study on long-term HL survivors and their siblings on health care utilization, health habits, and screening behavior. RESULTS: A total of 511 HL survivors (response rate of 50%, including survivors lost to contact) and 224 siblings (response ... [Abstract] [Full-text]

Articles on Hodgkin's Disease published 30 April 2008:

Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells.   Int J Cancer, 123(1): 56-65.

Although treatment of Hodgkin's lymphoma (HL) with a multi-drug approach has been very successful, its toxicity becomes evident after several years as secondary malignancies and cardiovascular disease. Therefore, the current goal in HL treatment is to find new therapies that specifically target the deregulated signaling cascades, such as NF-kappaB and STAT3, which cause Hodgkin and Reed-Sternberg (H-RS) cell proliferation and resistance of apoptosis. Based on the above information, we ... [Abstract] [Full-text]

Articles on Hodgkin's Disease published 29 April 2008:

Comparison of ICE (ifosfamide-carboplatin-etoposide) versus DHAP (cytosine arabinoside-cisplatin-dexamethasone) as salvage chemotherapy in patients with relapsed or refractory lymphoma.   Cancer Invest, 26(4): 401-6.

BACKGROUND: High dose chemotherapy with autologous stem cell transplantation is currently the treatment of choice for relapsed or refractory lymphoma patients. However, its applicability is mostly restricted to patients responding to salvage chemotherapy. Optimal salvage regimen for these patients is unclear. In this study, our aim was to compare the efficacy and toxicity profiles of DHAP (cytosine arabinoside, cisplatin and dexamethasone) and ICE (ifosfamide, carboplatin and etoposide) ... [Abstract] [Full-text]

Articles on Hodgkin's Disease published 28 April 2008:

Smoking and lymphoma risk in the European prospective investigation into cancer and nutrition.   Am J Epidemiol, 167(9): 1081-9.

Lymphomas are one of the few cancers that have been increasing in incidence over the past decades. So far, only a few established risk factors have been identified, including immunosuppression and viral infections. Recent evidence suggests etiologic heterogeneity of different lymphoma subtypes. Smoking may affect risk differently, depending on the lymphoma entity. The European Prospective Investigation into Cancer and Nutrition was used to study the role of smoking in the etiology of lymphomas ... [Abstract] [Full-text]

Articles on Hodgkin's Disease published 24 April 2008:

The CD4+CD26- T-cell population in classical Hodgkin's lymphoma displays a distinctive regulatory T-cell profile.   Lab Invest, 88(5): 482-90.

Little is known about the gene expression profile and significance of the rosetting CD4+CD26- T cells in classical Hodgkin's lymphoma (cHL). To characterize these T cells, CD4+CD26- and CD4+CD26+ T-cell populations were sorted from lymph node (LN) cell suspensions from nodular sclerosis HL (NSHL) and reactive LNs. mRNA profiles of stimulated and resting cell subsets were evaluated with quantitative RT-PCR for 46 genes. We observed a higher percentage of CD4+CD26- T cells in NSHL than in ... [Abstract] [Full-text]

Articles on Hodgkin's Disease published 22 April 2008:

Characterization of sperm chromatin quality in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy.   Hum Reprod, 23(5): 1044-52.

BACKGROUND: Although the incidences of testicular cancer and Hodgkin's lymphoma have increased in young men over the past decade, combination chemotherapy has improved survival. As fertility is of importance to these patients, characterization of sperm chromatin structure is needed. We assessed sperm chromatin in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy, in comparison with control community and idiopathic infertile volunteers. METHODS: DNA damage was assessed with ... [Abstract] [Full-text]

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